OraStripdx: The Science

Here’s the science behind what OraStripdx does. Each reference in the bibliography contains a link to the cited publication or abstract. In many of the papers, thiols are referred to as “VSCs” or “volatile sulfur compounds.”

Thiols are like alcohols but have a sulfur atom -SH instead of an oxygen -OH.

The color change on OraStripdx is directly related to the concentration of thiols in the oral fluid sample.

The concentration of thiols in oral fluid is directly related to periodontal disease activity. The concentration of thiols decreases after periodontal therapy.



The most prominent periodontal pathogens are anaerobes that produce thiols.

Pophyromonas species

Treponema species

Thiols destroy gingival tissue, compromising epithelial barrier function and promoting inflammation. Thiols degrade the periodontal ligament and induce resorption and loss of alveolar bone.

Periodontal disease is strongly linked to systemic diseases.

Multiple systemic diseases

Inflammatory markers/indices

Cardiovascular disease

Kidney disease

Cognitive dysfunction

Liver lesions

Even Stage 1 periodontal disease (gingivitis, no bone loss) is associated with systemic disease markers.

Routine use of OraStripdx is proven to enhance client compliance with recommendations.

The detection solution immobilized on OraStripdx is less irritating than children’s toothpaste.

Most adult dogs (and cats) have periodontal disease yet do not receive regular treatment for it. When pet parents realize periodontal disease is an uncontrolled infection that leads to pain, they become more inclined to take action in response to veterinary team recommendations.